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The 48HD SXC6C-TSL library is a bicyclic peptide library. Formed from the post translational cyclization of a linear SXCXXXXXXC (where X is a natural amino acid with the exception of cysteine) library with a proprietary two-fold symmetric linker. The library has a diversity of approximately 1 x 109 unique sequences. Click for more.
The New England BioLabs Ph.D.-7 library is a combinatorial library of random heptapeptides fused to a minor coat protein (pIII) of M13 phage. The displayed peptide is expressed at the N-terminus of pIII. The library consists of approximately 109 electroporated (i.e., unique) sequences. Click for more.
The New England BioLabs Ph.D.-12 library is a combinatorial library of random 12-mer peptides fused to a minor coat protein (pIII) of M13 phage. The displayed peptide is expressed at the N-terminus of pIII. The library consists of approximately 109 electroporated (i.e., unique) sequences. Click for more.
The New England BioLabs Ph.D.-C7C library is a combinatorial library of random peptides with a disulfide constrained loop, fused to a minor coat protein (pIII) of M13 phage. The displayed peptide, in the form AC-X7-CGGGS, is expressed at the N-terminus of pIII. The library consists of approximately 1 x 109 electroporated (i.e., unique) sequences. Click for more.
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One of the team members of 48HD can fill the form with your name, email and general description of your target based on the prior discussion, generate a quote, and create a cloud login on your behalf.
Soluble proteins are the most commonly requested targets. The proteins need to contain one of the affinity handles (e.g. biotin or Fc-tag) for immobilization of affinity resin of microliter plates. We also screen for ligands that bind to cell-based targets (GPCR receptors displayed on the surface of cells). Complex biomolecules (liposomes, vesicles, glycans, ECM, membrane preparations) can be used as targets if they can be conveniently immobilized on affinity resin or micro-titer well plates or isolated by centrifugation.
48HD screens genetically encoded, phage-displayed libraries of peptide macrocycles, bicycles and liner peptides. A full list is available here. Composition of libraries provided by 48HD is publically available on 48hd.cloud. Registered users can also download the entire composition of the library as a delimited file (>10 million entries)
Non-commercial screens are lower cost than commercial but they come with some restrictions on the use of the results.
|Cost||$10,000 or higher||$50,000 and higher|
|Target type||Proteins||Proteins, cells, complex biomolecues|
|Libraries||Available bicyclic, cyclic and linear libraries||All available libraries and custom libraries|
|Target exclusivity||No||Yes, see standard contract (Please contact us for more information)|
|Commercial use||No||Yes, with milestone payments (Please contact us for more information)|
|Affinity maturation||Additional cost||Included|
|Contract||Standard (available upon submission of the form)||Custom, in a 48HD template or Clients’ template|
|Contract adjustments||Minor only||Yes|
|Synthesis of leads||Additional cost||Can be included|
|Licensing of Selected Hits**||Yes||Yes|
*under the standard confidentiality terms, we do not disclose the names of the clients or their targets without prior approval of the Clients. The project and results are available to the client via a secure login at 48HD.cloud
** under the standard term: 48HD will, at Client’s request and expense, assign to Client all of 48Hour Discovery’s right, title and interest in the chemical structures described in the Selected Hits and any patents claiming such chemical structures, and will execute all instruments reasonably required by Client for the preparation, filing and prosecution of patent applications in any country or any division or continuation thereof or reissue of any patent issued on any such application.
Non-commercial contracts can be upgraded to the use for commercial purpose. The Client and 48HD enter into a new commercial contract and agree to the new terms. The Client reimburses 48HD the difference in cost between two contract types.
The system generates a quote that can be paid by Purchase Order, credit card or wire transfer.
Click here to download a presentation describing 48HD.