Chemically modified chemotypes

In the GE-Fragment Based Discovery (GE-FBD) screening service, we select ligands for your target from a phage display library that contains unnatural chemotypes and pharmacophores integrated atop chemically-constrained macrocycle portfolio. Installation of a chemical moiety that acts as a pharmacophore or “war-head” combined with synergistic peptide and macrocycle motifs affords ligands with higher affinity than parent pharmacophores. Examples of ready-made libraries with chemotypes are libraries of glycosylated macrocycles and glycopeptides for accelerated discovery of competitive inhibitors of carbohydrate recognition domains (CRD).

Workflow