We Work with Different Types of Targets

For targets with defined binding sites and applications such as epitope mapping.

Learn more >

For proteins with shallow binding sites, or for probing protein-protein interactions.

Learn more >

Please contact us to inquire.

section 2

Our In-House Encoded Libraries for Screening

 

We use genetically-encoded phage displayed peptides or peptide-derived libraries to discover ligands for your target. From a library of more than a billion molecules occupying the medium-sized chemical space (300-2000 Dalton), we ensure our molecules to occupy a “sweet spot” in protein-ligand recognition, which otherwise is hard to access by canonical small molecule drugs and biological (antibody-based) therapeutics. Currently we operate with four different types of in-house encoded libraries. We guarantee the quality and the diversity of each of our libraries for screening services. A summary of the properties of our genetically-encoded libraries is coming soon.

Linear or cyclized peptides of variable sizes. 

Peptide macrocycles with diverse cross-linkers. 

Constrained macrocycles with unnatural chemotypes. 

Customized macrocycle libraries tailored for your target. 

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The Discovery Workflow

 

Our screening technology centres around highly specific phage display panning process. For each different target, specific phage libraries are chosen and can be customized. We developed two screening processes to tackle simple and complex targets.

Section 1

Single-Round Screening for Simple Targets

Single-round screening is applied when protein targets have defined binding sites (e.g. antibodies). The outcome of such screening are linear epitope mapping or immunoprofiling. We recommend clients to use our in-house linear or cyclic libraries. Our single-round workflow is as following:

section 3

Multi-Round Screening for Complex Targets

Multi-round screening is used to probe protein-protein interactions, or when targets are more complex, e.g. with shallow binding sites, or targets that form complex. In this case, we recommend clients using our cyclic, bicyclic, or GE-FBD/customized libraries. Our multi-round workflow is as following:

See example full report >

(coming soon)

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Powerful Downstream Analysis Suite

We have our own unique Analysis Suite to perform a number of tasks:

  • Convert Illumina FASTQ file to user-friendly sequence table.
  • Perform comprehensive statistical analysis to identify putative binders.
  • Deliver visualization of sequencing data in easy-to-interpret reports.

Learn about our database >

(coming soon)

Introducing: “2+1” screening and maturation

(in development)